The Indiana PROSPECT builds on the Indiana Network for Patient Care (INPC) which is the nation’s largest health information exchange (HIE) that contains over 4 billion structured observations and 78 million text documents for more than 13 million patients across the entire network. This resource is already used for a variety of clinical outcomes and clinical effectiveness research. The project will enhance the infrastructure to capture richer clinical data and enhance the ability to incorporate patient outcomes, improve capture of device utilization data, incorporate genomic and other high throughput results, and identify patient for recruitment and enrollment technologies. Pilot projects are focused on medication treatment for Alzheimer’s patients. For more information visit http://www.regenstrief.org/centers/research-resources/indiana-prospect/.
- Securely leverage and expand the INPC health information exchanges for hypothesis-generating, exploratory, de-identified CER;
- Improve subject identification and study recruitment methods using clinical decision support software;
- Facilitate increased electronic capture of patient-centered outcomes from patients, proxies, and primary caregivers using easy, novel software-based approaches; and
- Support providers’, caregivers’, and researchers’ increasing need to work in teams by providing new tools for communication and co-management (e.g. collaborative care and research).
Primary Research Aims
Comparative effectiveness clinical trial of medication treatment for behavioral symptoms of Alzheimer’s disease in a group of real-world memory care clinics.
Primary care or ambulatory clinics, Specialty clinics
Geographic scope type
Locations of Focus
The five memory care practices cover the greater Indianapolis metropolitan area including urban and suburban settings.
Population Network Size
The estimated size of the network is 1,607,486 patients. The target study population size is 300 enrollees based on eligibility and refusals.
Indiana Network for Patient Care (INPC), eMR-ABC electronic Medical Record for Aging Brain Care, caTissue database, teleform process, telephone interviews (WinCATI)
Regenstrief, Institute Inc. (lead site); Wishard Health Services; Indiana University Health (Methodist Hospital and University Hospital), St. Vincent Health; Community Health Network
CER/PCOR Study Priority Populations
Low-income groups, Minority groups, Women, The elderly, Individuals with disabilities, Individuals who need chronic care, Individuals who need end-of-life care, Individuals who live in inner-city areas, Dementia, including Alzheimer's Disease (Brain and nerve conditions)
Donepezil, Galantamine, Rivastigmine
Outcome(s) of Interest
Medication discontinuation and adherence rates, Neuropsychiatric Inventory, and HABC Monitor
Acknowledgement of Funders
This project is supported by grant number R01HS019818-01 from the Agency for Healthcare Research and Quality, and is one of the ARRA-funded PROSPECT (Prospective Outcome Systems using Patient-specific Electronic data to Compare Tests and therapies) studies.
Creative Commons License
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