Project Title


Publication Date


Author Information

Paul Dexter, MD
Associate Professor of Clinical Medicine, Indiana University School of Medicine
Chief Medical Informatics Officer and Director of Clinical Effectiveness, Wishard Health Services
Scientist, Regenstrief Institute


The Indiana PROSPECT builds on the Indiana Network for Patient Care (INPC) which is the nation’s largest health information exchange (HIE) that contains over 4 billion structured observations and 78 million text documents for more than 13 million patients across the entire network. This resource is already used for a variety of clinical outcomes and clinical effectiveness research. The project will enhance the infrastructure to capture richer clinical data and enhance the ability to incorporate patient outcomes, improve capture of device utilization data, incorporate genomic and other high throughput results, and identify patient for recruitment and enrollment technologies. Pilot projects are focused on medication treatment for Alzheimer’s patients. For more information visit

Infrastructure Aims

  1. Securely leverage and expand the INPC health information exchanges for hypothesis-generating, exploratory, de-identified CER;
  2. Improve subject identification and study recruitment methods using clinical decision support software;
  3. Facilitate increased electronic capture of patient-centered outcomes from patients, proxies, and primary caregiv­ers using easy, novel software-based approaches; and
  4. Support providers’, caregivers’, and researchers’ increasing need to work in teams by providing new tools for communication and co-management (e.g. collaborative care and research).

Primary Research Aims

Comparative effectiveness clinical trial of medication treatment for behavioral symptoms of Alzheimer’s disease in a group of real-world memory care clinics.

Healthcare Settings

Primary care or ambulatory clinics, Specialty clinics

Geographic scope type


Locations of Focus

The five memory care practices cover the greater Indianapolis metropolitan area including urban and suburban settings.

Population Network Size

The estimated size of the network is 1,607,486 patients. The target study population size is 300 enrollees based on eligibility and refusals.

Informatics Platform/Tools

Indiana Network for Patient Care (INPC), eMR-ABC electronic Medical Record for Aging Brain Care, caTissue database, teleform process, telephone interviews (WinCATI)

Grant Type


Major Partners

Regenstrief, Institute Inc. (lead site); Wishard Health Services; Indiana University Health (Methodist Hospital and University Hospital), St. Vincent Health; Community Health Network

CER/PCOR Study Priority Populations

Low-income groups, Minority groups, Women, The elderly, Individuals with disabilities, Individuals who need chronic care, Individuals who need end-of-life care, Individuals who live in inner-city areas, Dementia, including Alzheimer's Disease (Brain and nerve conditions)

Treatment Comparators

Donepezil, Galantamine, Rivastigmine

Outcome(s) of Interest

Medication discontinuation and adherence rates, Neuropsychiatric Inventory, and HABC Monitor

Acknowledgement of Funders

This project is supported by grant number R01HS019818-01 from the Agency for Healthcare Research and Quality, and is one of the ARRA-funded PROSPECT (Prospective Outcome Systems using Patient-specific Electronic data to Compare Tests and therapies) studies.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.