The Population-Based Effectiveness in Asthma and Lung Disease (PEAL) Network
This project will create a new infrastructure to accelerate comparative effectiveness research (CER) in asthma and other lung diseases in diverse populations. The Population-Based Effectiveness in Asthma and Lung Diseases (PEAL) Network will create a highly detailed, standardized, linked computerized dataset from a state Medicaid plan and four health plans. CER will be conducted on asthma controller medications, evaluating adherence and other real-world factors. This project is innovative in that it will link claims, electronic medical records, patient and provider data, and will build new linkages with a Medicaid plan to include vulnerable groups who are disproportionately burdened by asthma. For more information, visit www.pealnetwork.org.
Build an innovative infrastructure for research on asthma and lung diseases by creating and linking standardized datasets from a state Medicaid population and four health plan populations.
Primary Research Aims
• Compare real-world adherence to and effectiveness of the major asthma controller regimens in diverse populations; and
• Conduct an applied methodological study that compares different design and analysis approaches for observational comparative effectiveness research.
Primary care or ambulatory clinics, Inpatient facilities
Geographic scope type
Locations of Focus
multiple regions across the US. Areas covered by the network include the states of Georgia, Maine, Massachusetts, New Hampshire and Tennessee; the cities of St. Paul, Hudson, and New Richmond in Minnesota; and the region of northern California (Napa to Fresno)
Population Network Size
3 million patients
Harvard Pilgrim Health Care (lead site); HealthPartners Research Foundation; Kaiser Permanente Northern California; Kaiser Permanente Southeast; Kaiser Permanente Northwest; Kaiser Permanente Mid-Atlantic; Vanderbilt University; Channing Laboratory
CER/PCOR Study Priority Populations
Children, Individuals who need chronic care
Outcome(s) of Interest
Adherence; prevention of adverse events; costs and cost-sharing; modifiable risk factors (based on PRO and provider surveys); asthma exacerbations and health care use
Acknowledgement of Funders
PEAL is funded by the Agency for Healthcare Research and Quality (AHRQ) through the American Recovery & Reinvestment Act of 2009, Grant 1R01HS019669.