Submission Type

Original Article


Significant national investment in developing key infrastructure to support Comparative Effectiveness Research (CER) necessitates developing techniques for information and knowledge management, such as those pioneered by the Clinical Informatics community. Motivated by the need for resources that specifically track the literature at the intersection of CER and Clinical Informatics, this report provides an annotated bibliography of 132 articles in the peer-reviewed literature. In particular, this review emphasizes publications that provide insight into the uses of clinical informatics for population-based research. The selected articles address the use of clinical informatics for CER from a historical perspective and consider the development and application of several key projects, platforms, networks, and technologies that are most relevant for CER. The review also includes information on the structured approach used to identify key papers that are relevant to the emerging body of literature related to developing CER infrastructure with prospective electronic clinical data.